Molecular nexopathies: a new paradigm of neurodegenerative disease
نویسندگان
چکیده
منابع مشابه
Molecular nexopathies: a new paradigm of neurodegenerative disease
Neural networks provide candidate substrates for the spread of proteinopathies causing neurodegeneration, and emerging data suggest that macroscopic signatures of network disintegration differentiate diseases. However, how do protein abnormalities produce network signatures? The answer may lie with 'molecular nexopathies': specific, coherent conjunctions of pathogenic protein and intrinsic netw...
متن کاملGenus Boswellia as a new candidate for neurodegenerative disorders
Neurodegenerative diseases, characterized by progressive loss of neurons, share common mechanisms such as apoptotic cell death, mitochondrial dysfunction, inflammation, and oxidative stress. Genus Boswellia is a genus in the Burseraceae family. It comprises several species traditionally used for treatment of chronic inflammatory diseases, cerebral edema, chronic pain syndrome, gastrointestinal d...
متن کاملDisintegrating Brain Networks: from Syndromes to Molecular Nexopathies
In this issue of Neuron, Raj et al. (2012) and Zhou et al. (2012) use graph theory to suggest that neurodegenerative diseases spread diffusively via intrinsic brain networks. These studies provide a powerful model for understanding and predicting disease-specific profiles of neurodegeneration.
متن کاملApocynin, a Low Molecular Oral Treatment for Neurodegenerative Disease
Accumulating evidence suggests that inflammatory mediators secreted by activated resident or infiltrated innate immune cells have a significant impact on the pathogenesis of neurodegenerative diseases. This may imply that patients affected by a neurodegenerative disease may benefit from treatment with selective inhibitors of innate immune activity. Here we review the therapeutic potential of ap...
متن کاملNew hope for devastating neurodegenerative disease
When a credible new idea emerges for repositioning a diabetes drug for devastating brain disorders, it is essential to give that idea attention. In this issue of Brain, the team led by Dr Meissner provide such a possibility (Bassil et al., 2017). More specifically, they provide a solid rationale for considering an FDA approved drug, exendin-4, as an entirely new approach for treating multiple s...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Trends in Neurosciences
سال: 2013
ISSN: 0166-2236
DOI: 10.1016/j.tins.2013.06.007